DecisionDx®-UM Accurately Predicts the Risk of Your Eye Cancer Spreading

One of the Primary Challenges for Healthcare Providers in Managing Uveal Melanoma Is Predicting the Potential for the Disease to Spread

Fortunately, patients today have access to the DecisionDx-UM gene expression profile (GEP) test, which predicts a patient’s risk based upon their tumor’s own unique biology. The test was developed by ocular oncologist Dr. J. William Harbour, currently at Bascom Palmer Eye Institute, and exclusively licensed to Castle Biosciences Inc.

DecisionDx-UM Uses Tumor Biology to More Accurately Predict the Risk of Your Cancer Recurring or Spreading

DecisionDx-UM is the most widely used prognostic test in uveal melanoma in the U.S. It is used to predict risk of a patient’s tumor spreading in five years. According to studies published in Clinical Ophthalmology and Journal of Oncology, the DecisionDx-UM test has a significant impact on the management of uveal melanoma. Ophthalmologists report that they are more likely to increase frequency of disease monitoring or recommend clinical trials for those patients whose test results showed they were at high risk of metastasis.

The DecisionDx-UM test is extremely valuable in guiding a patient’s care following treatment of the original eye tumor. It measures the activity or “expression” of certain genes within the tumor to determine its risk profile, or Class:


Class 1A

Class 1A

Low risk, with a 2% chance of the eye cancer spreading over five years

Class 1B

Class 1B

Intermediate risk, with a 21% chance of metastasis over five years

Class 2

Class 2

High risk, with 72% chance of metastasis over five years

Genomic Testing Adoption by Healthcare Professionals

Since its availability in 2009, over 11,000 patients have been clinically tested with DecisionDx-UM, making it the most widely used uveal melanoma prognostic test in the US. To date, more than 300 healthcare providers have used DecisionDx-UM to help guide the management of their patient's cancer.



patients tested since 2009
More than


healthcare providers have ordered

See if DecisionDx-UM is Right For You

It's Your Decision

Your Healthcare Professional is a trusted source of information. But the decision to get tested is yours to make. Download the Discussion Guide for some helpful tips on how to start the conversation. 

"I wasn’t given the information and almost missed my chance to get tested."

Hear From Other Patients

Learn How DecisionDx-UM Has Made Significant Impact on the Lives of Other Uveal Melanoma Patients.


What’s Next?

Understanding the Results

How Do You Get a
DecisionDx-UM Test?